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Introduction (continued) The proportion of adults who are current smokers has declined from 42% in 1965 to 21% in 2006

According to the Centers for Disease Control and Prevention (CDC), Overdoses involving opioids killed nearly 69,000 people in 2020, and over 82% of those deaths involved synthetic opioids

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More specifically, WP smoke contains significantly more carbon monoxide, equivalent to that from 10 cigarettes per day 3

N Engl J Med 344 : 17291732