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6 Pharmacological Effects Polycyclic aromatic hydrocarbons from smoke inhalants induce cytochrome p450 and UDP-glucuronosyltransferase systems, thereby increasing the metabolism of opioids, benzodiazepines, propofol, most neuromuscular blockers, and volatile anesthetics

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This type is often associated with chronic acid reflux (gastroesophageal reflux disease or GERD) and obesity, which can cause changes in the esophageal lining known as Barretts esophagusa precursor to adenocarcinoma

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