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The original "Sad Affleck" meme (not to be confused with the smoking format) refers to the look of dismay worn by Affleck during a Batman v Superman press interview in 2016, which went viral paired with Simon & Garfunkel's "The Sound of Silence." The two memes have always been linked in the public consciousness different moments, same essential emotional frequency

In Model 2, in addition to all covariates included in Model 1, we added one of the two GRS described above

The results linked heavy smoking to 28 separate health conditions including

I have lost three articles of handwear in as many weeks

Smokers have more lines, wrinkles, undereye bags, and sagging skin than non-smokers do