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Global Tobacco Control Tobacco use is a major preventable cause of premature death and disease worldwide

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27 Studies measuring biomarkers of the dangerous substances in tobacco smoke (see Section 12.5.6) find that, compared to quitting completely, smokers who cut down still have relatively high levels of biomarkers of oxidative stress (an imbalance of free radicals and antioxidants in the body) such as glutathione 28 and other metabolites such as thiocyanate, 29 TNE-2, NNAL, NNN, 2-Fluorene, HPMA, CYMA, and MHB3