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E-cigarettes induce the production of pro-inflammatory mediators and proteases, damaging lung connective tissue and parenchymal cells, suppressing alveolar macrophage phagocytic and defensive capabilities, and further increasing susceptibility to respiratory infections [78]

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A., & Cinciripini, P

[3] The resulting snuff was then stored in airtight ornate bone bottles or tubes to preserve its flavor for later consumption

These analyses revealed a steady but unspectacular decrease in smoking prevalence since 2011, continuing a gradual decline going back several decades