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Le Foll and Goldberg, 2009), and switching smokers to very low nicotine content cigarettes results in only a limited reduction in cigarettes smoked per day ( While there are numerous factors other than nicotine content/yield that could contribute to the greater abuse liability of cigarettes versus ANDs (e.g., sensory effects, marketing, etc.), cigarette smoke (CS) contains considerably higher levels of several behaviorally active non-nicotine constituents including monoamine oxidase (MAO) inhibitors (e.g., the -carbolines harmane and norharmane, also called harman and norharman), minor tobacco alkaloids (e.g., nornicotine, anabasine), and volatile organic compounds (VOCs) (e.g., acetaldehyde, toluene) (e.g., Margham et al., 2016