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The report also mentions that countries and regions such as the United States, United Kingdom, and the European Union have already regulated synthetic nicotine and banned the addition of flavors in order to prevent youth access to e-cigarettes

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A large fair-rated US longitudinal study that excluded former and current smokers, but included both reported on snuff and chewing tobacco together, reported higher CHD mortality (OR = 1.25

Otherwise, its mostly to do with THC:CBD ratios and the abundance of different terpenes

World Population Prospects Highlights, 2019 Revision Highlights, 2019 Revision