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Synthetic cannabinoids (K2/Spice) are more unpredictable and have a stronger link to medical emergenciesbut safer is the wrong goal

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However, diagnostic procedures, such as characterization of anion gap (or osmolal gap, defined as the discrepancy between the measured and calculated osmolalities) (Lim et al., 2014), and evaluation for the presence of lactic acidosis, could be of potential value in suspected cases of high-dose PG toxicity from extensive vaping