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To understand how central carbon metabolism may be rewired to support purine nucleotide synthesis, we performed 13 C-glucose tracing experiments, which confirmed that CR hi cell lines had significant enrichment of 13 C into tricarboxylic acid intermediates (Figure 8B and Supplemental Figure 6, AD)

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What happens is that you still get some dose of nicotine, but you are no longer have exposure to chemicals from the tobacco

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