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In 2016 the Royal College of Physicians concluded that "large-scale substitution of e-cigarettes, or other non-tobacco nicotine products, for tobacco smoking has the potential to prevent almost all the harm from smoking." Studies published in 2016 and 2017 showed that smokers who switch to e-cigarettes dramatically reduce their exposure to hazardous chemicals generated by tobacco combustionas dramatically as smokers who switch to nicotine replacement products such as gum or patches (a finding confirmed by a 2019 study of Juul e-cigarettes, the dominant brand in the United States)

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Structural, functional, and molecular impact on the cardiovascular system in ApoE-/- mice exposed to aerosol from candidate modified risk tobacco products, carbon heated tobacco product 1.2 and tobacco heating system 2.2, compared with cigarette smoke

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