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NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases

As mentioned, with repeated exposure to smoking or drug abuse, the brain associates them with dopamine production

INTRODUCTION Tobacco use remains the leading preventable cause of morbidity and premature mortality worldwide, responsible for approximately 8 million deaths annually and a disproportionate share of the global burden of chronic non-communicable diseases (NCDs), including cardiovascular disease, type 2 diabetes, cancer, and chronic obstructive pulmonary disease 1,2

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Whilst the profits are not as much as illicit drugs, the penalties less severe and the risk reward payoff is a lot more favourable to organised crime groups. According to the release