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Nicotine is a parasympathomimetic substance that is found in cultivated tobacco plants (Nicotiana tabacum) and is as addictive as cocaine and other illegal substances

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Talk to your doctor, nurse, or pharmacist: If you are pregnant or breastfeeding, If you are in the hospital because of heart disease (including heart attack, heart rate or rhythm disorders, angina, high blood pressure, or stroke)

Sourcing: CDC, American Lung Association, National Institutes of Health, Anxiety and Depression Association of America, National Cancer Institute, American Cancer Society, World Health Organization

So this could be the reason for addiction and dependence which further prevents the users from quitting smoking