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The harm from traditional cigarettes comes predominantly from combustion byproducts including carbon monoxide, tar, and the thousands of chemicals produced when tobacco burns at above 600 degrees Celsius

They allow us to generate human-relevant data that will be of interest not just to industry and research scientists, but also to regulatory bodies

They think itll be easy for them to quit later on, but once your brain gets that taste of nicotine, it actually wont. According to the National Institutes of Health (NIH), smoking is the leading cause of preventable death in the U.S