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The glacial epoch was a local phenomenon. WEST of Cleveland, the terrain became increasingly flat

Participants with histories of major illnesses, other substance abuse (besides nicotine), psychotropic medication use, neurological and psychiatric diseases, and systemic diseases (i.e., diabetes or hypertension) were excluded

For decades, answering these questions was hindered by numerous factors

Significant ambiguity can come from existing definitions of tobacco or nicotine products that may be overly narrow or those that rely upon the terminology of tobacco-derived or of tobacco leaf. Accordingly, in alignment with the action taken by Congress, local leaders may want to ensure that state statute and local ordinances appropriately regulate tobacco products containing nicotine from any source

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