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Most of these estimations do not use factual data (other than PM2.5 levels) from the studied location with no attempt to modulate the impact of air pollution on mortality (ex: data is often calibrated in cities where industrial, traffic and urban pollution is potentially considerably more toxic than biomass burning or desert dust)

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The agency is tasked with determining whether these products have a benefit to adult smokers sufficient to overcome the public health threat posed by the well-documented, alarming levels of youth use of such products. Flavored ENDS products are extremely popular among youth, with over 80% of e-cigarette users between ages 12 through 17 using one of these products, said Mitch Zeller, director of the FDAs Center for Tobacco Products