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Upon withdrawal, these issues can persist, further compounding stress levels and triggering elevated cortisola primary stress hormone linked to increased cravings, irritability, and relapse risk

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[158] A 2016 study reported that some e-liquids contained tobacco alkaloids such as nornicotine, anabasine, anatabine, and TSNAs, such as N -nitrosonornicotine (NNN), 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone (NNK), [15] nitrates, and phenol