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Next, to further evaluate the performance of the classical force fields, we performed a 100-ns polarizable Drude simulation of the full-length Pc ncAAAD, during which calcium binding at site A was characterized by ~100% residence probability, in line with the overall high residence probabilities in the initial 100-ns as well as the complete 6-s CHARMM simulations (100.0% and 71.3%, respectively, see Supplementary Fig