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It has to be mentioned here that the nicotine effects observed in cell cultures do not reflect exclusively a direct interaction of nicotine with mitochondrial enzymes, but can also result from the activation of signaling pathways secondary to mitochondrial function or ROS production, which are not observable in experiments with isolated mitochondria

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A smoker for most of his life who once quit for a decade, Pia said he recognized the dangers of such products on youngsters and had hoped his own children would not take up the habit, though two of his six children did

Patoulias D, Boulmpou A, Papadopoulos CE, Doumas M