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The exact time period is unknown, but is mostly around the 1930's or 1940's

5 The measurement of cotinine--a primary metabolite of nicotine with a half-life of 16 to 18 hours that is detectable in urine, saliva, or serum--is a reliable method of determining use of or exposure to cigarettes or other tobacco products over a period of 2 to 3 days

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Evaluation of ICA-AROMA and alternative strategies for motion artifact removal in resting state fMRI

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