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To be sure, CBDs hepatotoxicity potential is largely unproven, with liver injury being possible primarily with very high doses, but the risk of adverse events increases when CBD is combined with certain medications.45 CBD is metabolized by cytochrome P450 (CYP) liver enzymes , the same ones that metabolize almost half of all prescription drugs, including but not limited to:18 Anticonvulsants Immunosuppressants Protease inhibitors Anti-infectives Statins Antidepressants Blood thinners Oral contraceptives Antipsychotics At the very least, combining CBD with any such medication may result in therapeutic failure of the medication

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Smoke on a plane From the 1940s til the 1970s, airlines not only allowed passengers to smoke onboard, they handed out adorable sample packs (tobacco companies knew a captive audience when they saw one)