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The reverse gateway suggests that a heightened risk of nicotine dependence is the most important health consequence of early frequent cannabis use [13] United States [edit] According to the Global Drug Survey only 8% of Americans use tobacco with cannabis while smoking joints

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Consider Nicotine-Free Options (with caution): If reducing nicotine exposure is a goal, nicotine-free e-liquids eliminate that specific risk, but remember PG and flavorings might still pose some level of irritation or unknown long-term risk

529 Wynd, 2005

Personally, I aim at the tree and go from there when making a decision on the second shot