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[47] The most well-known hereditary influence related to nicotine dependence is a mutation at rs16969968 in the nicotinic acetylcholine receptor CHRNA5 , resulting in an amino acid alteration from aspartic acid to asparagine

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This combustion process creates: Smoke Tar Ash Thousands of chemical compounds Because tobacco is burned directly, cigarettes produce the highest amount of harmful byproducts among the three categories