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The traveller seeks a goal, but the dancers move blindly and aimlessly among the points of the compass

These structures play a crucial role in regulating Ca 2 homeostasis through various signaling mechanisms: The IPR-VDAC-MCU Pathway facilitates Ca 2 transfer from the ER to mitochondria via inositol 1,4,5-trisphosphate receptors (IPRs) on the ER membrane, voltage-dependent anion channels (VDACs) on OMM, and MCU on IMM

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Lack of Opa1 results in mitochondrial fragmentation, reduced cristae, and OXPHOS, and similarly leads to embryonic lethality in mouse models (Quintana-Cabrera and Scorrano, 2023)

Conklin CA, Tiffany ST