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The following covariates were included to control for any potential confounding effects: gender (male vs female), race/ethnicity (Non-Hispanic White vs Non-Hispanic Black vs Hispanics and all others), age, education level (lower than high school vs high school or higher), body mass index (BMI, kg/m 2 ), and ratio of family income to poverty 4

Tobacconists represent 15 to 20% of the distribution in the sector by value, as well as specialised shops numbering some 3 300, accounting for 50% of sales

FDA has had the authority to require premarket authorization of all e-cigarettes and other electronic nicotine delivery systems (ENDS) since August 2016, but thus far has exercised enforcement discretion regarding the need for premarket authorization for these types of products

The study, published in the journal Tobacco Control, was funded by the Medical Research Council and the Natural Environment Research Council.

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