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NAMs are any technology, methodology, approach, or combination that can provide information on chemical hazard and risk assessment that replaces or reduces the use of animals, including in silico , in chemico , in vitro , and ex vivo approaches (EPA, 2018b)

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The study, published in the journal JAMA, demonstrates an association between long-term exposure to major air pollutants especially ozone with an increase in emphysema seen on lung scans