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We speculate, that modulating homeostatic balance in microglia, could have promising therapeutic potential in withdrawal, tolerance, and abstinence-related neural adaptations in nicotine addiction, in the adolescent brain

Youth in grades 6-12 could be cancelling out any of the healthier benefits of smokeless tobacco by using it on top of cigarettes, the researchers said, adding that they could even be increasing their risk for tobacco-related illnesses, Everyday Health reported

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Only if these four key elements work in unison can population-level THR be considered a realistic possibility