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The hardest window is the first 4872 hours, when symptoms like irritability, headaches, and intense cravings peak

The strongest design would follow an entire population of youth beginning at an age at which risk of use of any product is negligible (e.g., 10 years old) and investigate time-varying associations between e-cigarette ever use and later combustible tobacco cigarette use at multiple developmental stages throughout the entire period of risk (e.g., up until age 29), while using multiple methods to establish temporal precedence of vaping relative to smoking

Stage a Thoughtful Intervention: Plan a structured and respectful intervention with the help of a professional

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