The key culprit here is nicotine, which is a known vasoconstrictor (something that reduces blood flow throughout the body the opposite of a vasodilator like nitric oxide)
Ease of use: With their pre-rolled format, these cigarettes are ready to go, making them the perfect option for those seeking a quick, hassle-free moment of relaxation
No ice, no tartness, just straight candy
Lawrence Weschler, Valkyries Over Iraq, Harpers Magazine , November 2005, p
Also, the study finds that people who vape and also smoke tobacco, and who test positive for COVID-19, complained of labored breathing and had more frequent emergency department visits than those who did not vape