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High stress is known to deplete the body's reserve of catecholamines like norepinephrine

Side effects are rare and generally very mild, which may include fatigue, dry mouth, drowsiness, nausea

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Moreover, when the data from rats exposed to regular cigarettes (which led to an anxiolytic effect) were included in the analysis there was no correlation between any variable and the behavioural output, as expected [SOD (r = 0.6374, p = 0.07), TBARS (r = 0.32, p = 0.13) and in the number of cells in the BALF (r = 0.21, p = 0.31)]