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The curse was put into effect on November 17, 1996, in the X-Files episode Musings of a Cigarette Smoking Man. In the episode, the enigmatic Cigarette Smoking Man, played by William B

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In 1942, however, cannabis was removed from the Pharmacopoeia due to its abuse potential, variation in its quality, fear of its unidentified active compounds, and because other conventional medications that were known for their efficacy were used as alternatives (Zuardi 2006)