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The extraction process uses real tobacco leaves rather than synthetic flavor compounds

Data from South America are further limited, but older studies in Brazil (2015) indicate that 2.1% had ever tried e-cigarettes 22

Benzene : Long-term exposure to benzene can damage the bone marrow, leading to a low red blood cell count or anemia

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Aphthous stomatitis Aphthous stomatitis , [2] or recurrent aphthous stomatitis ( RAS ), commonly referred to as a canker sore or salt blister , is a common condition characterized by the repeated formation of benign and non-contagious mouth ulcers (aphthae) in otherwise healthy individuals