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277 The reported variation in the weight loss for the different GLP-1 analogues currently used to treat T2D is possibly related to their ability to penetrate the CNS, allowing for central GLP-1R binding

They used inducible let-7 transgenic mice and measured the metabolic changes such as glucose tolerance and signaling activity and found that inducible let-7 transgenic mice showed decreased glucose tolerance

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At the cellular level, it improves calcium handling in muscle cells, supporting faster recovery

A clinical study demonstrated (Tung-Sheng et al., 2011) that a 1:1 mixture of epigallocatechin-3-gallate and Amla (Emblica officinalis) significantly enhanced antioxidant defenses in patients with diabetic nephropathy, synergistically improving clinical outcomes