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These findings provide a framework for future basic research and potential therapeutic interventions targeting splicing defects associated with various diseases

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The siRNA sequences targeting SLC7A11, GCLC, and GSS were synthesized by Genepharma (Suzhou, China)

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We performed glucose and insulin tolerance tests (GTT and ITT, respectively), timing the assays such that mice in all groups were fasted for similar lengths of time

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Solid tumors, such as osteosarcoma, generally suffer from an inadequate oxygen supply due to the rapid proliferation of cancer cells, incomplete vascularization, and uneven distribution

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