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In addition to inflammatory and neuroendocrine mechanisms, IR has been associated with mitochondrial dysfunction and impaired brain energy metabolism, particularly in regions central to mood regulation, such as the prefrontal cortex and limbic system [2,4,6]

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[DOI] [PubMed] [Google Scholar] 59.Hochgrfe K., Sydow A., Matenia D., Cadinu D., Knen S., Petrova O., Pickhardt M., Goll P., Morellini F., Mandelkow E., et al

Alternatively, the levels of reactive electrophiles in the body can be inferred from the adduct concentrations in the DNA/RNA in cells and prominent blood proteins (e.g