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Incubation without immobilised HSA was used as reference

Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): a multicentre, randomised, open-label, parallel-group, phase 3 trial

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Similar to NPG treatment, deletion of CSE attenuated NAC- and Cys-induced H 2 S generation (Figure S2C) and likewise attenuated the NAC- and Cys-induced mt-roGFP2 response (Figure 3B, left panels), but not the 3MP- and H 2 S-induced mt-roGFP2 responses (Figure 3B, right panels)

How it works Activates the ghrelin receptor (GHS-R1a) to trigger a natural GH pulse