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Description

This mechanism aimed to inhibit CB1 signaling without crossing the blood-brain barrier, sidestepping neuropsychiatric side effects that doomed earlier small-molecule CB1 inhibitors

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The upper arm works but is awkward to self-administer, so it usually needs another person

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Clonidine works by stimulating the inhibitory alpha-2 adrenergic receptors in the medulla oblongata in the central nervous system

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