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retatrutide in Phase III Metabolic focus: Obesity, overweight, type 2 diabetes, sleep apnea, osteoarthritis, MASLD/MASH and cardiovascular/renal outcomes Eli Lillys obesity portfolio includes Zepbound, the newly approved oral GLP-1 drug Foundayo and the Phase III candidate retatrutide

222,223 Moreover, activation of cell surface receptors such as NMDARs, AMPARs, mGluR, IGFR and TrKB is closely linked to activation of the ERK/MAPK and PI3K/mTOR pathways (Fig

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