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Long-term deficiencies may result in severe complications, such as nerve damage or cognitive decline

Oral Supplementation Studies suggest that about 56% of an oral B12 supplement is absorbed, but this is largely dependent on the capacity of intrinsic factor (a glycoprotein released by the stomach that is needed for B12 absorption)

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AOD-9604 has been studied as acting through beta 3 adrenergic receptors on adipocytes and possibly on lipase activation