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A dose administered during the course of the day promotes improved sleep on the subsequent night and for several nights thereafter a temporal profile incompatible with direct sedation and consistent with a neuromodulatory mechanism acting on sleep homeostatic systems
Additionally, accelerated ATP degradation under pathological conditions (e.g., intense exercise and ischemiareperfusion injury) promotes hypoxanthine accumulation, creating a secondary drive for UA overproduction (Uskudar Cansu et al., 2019)
Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis Hum Exp Toxicol
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