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In a study of real-world use of GLP-1s, Weiss et al

doi: 10.14310/horm.2002.1322 89 CareADAbbasSKPellJSeitzPKCooperCW

Meta-analyses of randomized trials corroborate these findings: one large review of 27 RCTs reported no significant difference in suicidality between GLP-1 RAs and placebo (RR 0.76) [48], while another meta-analysis including 25 trials similarly showed no association across multiple subgroups and endpoints (RR 0.84) [49]

Its no secret that GLP-1 drugs like Ozempic and Wegovy are dominating headlines and prescriptions