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The study demonstrates that AR is a key negative regulator of stromal fibroblast activation into CAFs by parallel suppression of senescence and CAF effector genes

Storage is at 28C with a stability window of up to 60 days post-reconstitution

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Meanwhile, CRFA issued a note reiterating its Hold opinion on Novo, calling the results disappointing but acknowledging that the drugmaker continues to be a market leader in the obesity medication space

The two-domain binding mode suggests that the C-terminus of the peptide hormone initiates recognition with the ECD