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But some studies have led to questions about high-level B12 doses in those not vitamin B12 deficient or at risk of a deficiency

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Shin E-J, Jeong JH, Bing G, Park ES, Chae JS, Yen TPH, Kim W-K, Wie M-B, Jung B-D, Kim HJ, Lee S-Y, Kim H-C (2008) Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice