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use a titration series with appropriate vehicle and pathway controls

Lastly, patients must be informed about the risks of GLP-1s in the context of eating disorders, including rapid weight loss, malnutrition, refeeding syndrome and the potential worsening of cognitive and behavioural symptoms

This concern is not unfounded, as gastrointestinal side effects, including diarrhea, are often reported among those using this medication

Regulatory guidance for orally administered drugs typically requires that the 90% confidence intervals for key pharmacokinetic parameters (Cmax and AUC) fall within predefined limits, commonly 80%125% of a reference product (Rowland and Tozer, 2011)

Exendin-4 promotes osteogenic differentiation of adipose-derived stem cells and facilitates bone repair