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Sema was given twice per week for 20 weeks, starting on Day 0 of the study at 10 g/kg, and no titration of Sema was given due to the low dose regimen

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The choice of combination therapy should be individualized based on patient-specific factors, including baseline glycemic control, hypoglycemia history, renal function, and cardiovascular risk profile

Store reconstituted solution at 28C and use within 4 weeks