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Early studies suggest potential benefits in conditions involving impaired intestinal motility or altered gut hormone signaling, including metabolic disorders and certain gastrointestinal diseases

But prolonged exposure to high leptin causes the brain to become leptin resistant : the hypothalamus stops responding effectively to the signal, in the same way that ears habituate to background noise

10.3390/neurolint14020025 Neurol

There have been rare reports of pancreatitis (inflammation of the pancreas) in patients taking GLP-1 receptor agonists, though a definitive causal relationship remains uncertain

This may reflect differences across the studies including the duration of illness, age (in particular, the lower mean age of both healthy controls and MDD patients in the studies of occipital cortex), and medication use