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Proposed pathways include modulation of multiple neurotransmitter systems (influencing serotonin, dopamine, norepinephrine, GABA, glutamate levels), possible involvement of NMDA receptors, alpha-1 adrenergic signaling (e.g., potentiating pineal acetyltransferase activity), inhibition of somatostatin release via dopaminergic routes, reduced ACTH/cortisol for stress buffering, and stimulated growth hormone or somatoliberin secretion

Camilleri, 2019

Some patients start with weekly sessions and taper to monthly maintenance

Adults and children over 12 can take 15-30 milliliters every 15 minutes until nausea symptoms dissipate, not to exceed 5 doses within 1 hour

Melanin is what makes the skin colour, and in case of excess production or unevenness, dark spots and pigmentation would be observed