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and patients with glutathione-S-transferase M1 (proinflammatory-cytokine producer macrophages) null and M1 and T1 (Type 1 helper CD4 + lymphocytes) double null polymorphisms had increased mortality suggesting that antioxidant therapy becomes fundamental for those patients (109)

Furthermore, previous studies indicate that charged residues adjacent to aggregation-prone regions act as gatekeepers to prevent aggregation 41

6,23,57 Astroglial reactivity or reactive astrogliosis The concept of astrocytic reactivity or reactive astrogliosis (we shall use these two terms interchangeably) as an almost universal part of neuropathology is deeply rooted

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There is just no denying that patients with AGA are at risk for metabolic syndrome and this should be evaluated at the start