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Makino T, Umegaki H, Suzuki Y, Yanagawa M, Nonogaki Z, Nakashima H, et al

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Disarmed versions: retain supportive or educational content but remove the active, efficacy-driving components (e.g., CBT exercises, feedback loops)

The 2026 EASO pharmacotherapy update explicitly ranks tirzepatide above semaglutide for weight loss, while supporting semaglutide as the better-documented option for liver fibrosis endpoints in MASH [1]