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The 500 mcg per-capsule dose mirrors the per-day intake used in the bulk of rodent oral studies, and the gastric origin of the parent molecule provides a biological rationale for stability through the GI tract a feature documented across multiple oral-administration preclinical models

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a peripheral motor system under continuous inhibitory drive is more likely to recalibrate toward its baseline, because the body generally defends the timely delivery of nutrients and the avoidance of prolonged gastric retention