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C-MYC Inhibited ferroptosis and promoted immune evasion in ovarian cancer cells through NCOA4 mediated ferritin autophagy

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[5] [6] The effects of persistent high cortisol are wide-ranging and can include: Weight gain , particularly around the abdomen and face Insulin resistance and increased risk of type 2 diabetes Hypertension (high blood pressure) Osteoporosis and increased fracture risk Mood disturbances , including anxiety and depression Immune suppression , leading to increased infection susceptibility Muscle weakness and skin changes The relationship between cortisol and metabolic health is particularly significant

In these cases, glutathione (GSH) levels are well below the normal concentration and therefore feedback inhibition of GCL is absent